Intralesional therapy-
Concentration of a drug directly into skin lesions without significant!!
Intralesional therapy in dermatology
Intralesional therapy is a simple, safe office procedure constituting an integral part of the dermatological practice.In this therapy, one injects a higher concentration of a drug directly into skin lesions without significant systemic absorption.
The different drugs used for intralesional therapy are corticosteroids,5- fluorouracil, PRP, Interferons, Bleomycin, methotrexate, cryotherapy, sclerosants, PRP etc.
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The advantages of intralesional therapy are its faster and prolonged duration of action, penetrates deeper than topical therapy and can be combined with other modalities of treatment for synergistic action.
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What is Intralesional corticosteroid used for?
Intralesional corticosteroid mainly, Triamcinolone acetonideis used for keloids, alopecia areata, nodulocystic acne, hidradenitis suppurativa, localized and nail psoriasis, prurigonodularis, cutaneous lupus erythematosus, vitiligo, etc.
How long one should take intralesional injections?
It is given in an interval of 3–6 weeks between two consecutive injections. The number of injections depends on the disease, site of lesions, response to previous injections, age of the patient and other comorbid conditions.
What are the side effects ofIntralesional corticosteroid?
Atrophy of skin, pain at injection site, hyper- or hypopigmentation, telangiectasias, secondary infection, stellate pseudoscars, hypertrichosis, tachyphylaxis could be possible side-effects of intralesional corticosteroid injections.
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5-Fluorouracilis used for keloids, warts, chronic plaque psoriasis, Squamous cell carcinoma and Basal cell carcinoma.
Platelet-rich plasma has been used for treating alopecia areata, acne scar revision, non-healing ulcers, lipodermatosclerosis, striaedistensae, androgenetic alopecia, lichen sclerosus and vitiligowith promising results, at weekly intervals.
Together with steroids,liquid nitrogen is used for the treatment of keloids and hypertrophic scars.